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pentobarbital will lessen the level or result of copyright topical by affecting hepatic enzyme CYP2B6 metabolism. Small/Significance Not known.pentobarbital increases effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Warning/Monitor. Coadministration of ifosfamide with CYP2B6 inducers could increase metabolism of ifosfamide t